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The effects of aversive stress on hippocampal structure and function have been linked to stress-induced elevations in glucocorticoids.

Normalizing corticosterone levels prevents some of the deleterious consequences of stress, including increased anxiety and suppressed structural plasticity in the hippocampus."Previous studies have shown that high stress levels have a negative impact on learning and memory. I have stated before, namely in my recent presentation at the H+ Summit, that some amount of stress, of a specific type, can actually be good for you, and can improve your cognitive functioning.

Adult male rats were exposed to a sexually-receptive female once (acute) or once daily for 14 consecutive days (chronic) and levels of circulating glucocorticoids were measured.

Separate cohorts of sexually experienced rats were injected with the thymidine analog bromodeoxyuridine in order to measure cell proliferation and neurogenesis in the hippocampus.

In addition, brains were processed using Golgi impregnation to assess the effects of sexual experience on dendritic spines and dendritic complexity in the hippocampus.

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